Effects of 14 days of prophylactic resveratrol supplementation in trained endurance runners upon the inflammatory markers TNF-a, IL1β, and IL-6 following a single bout of eccentric exercise

Background Resveratrolis a natural polyphenol found in peanuts and grapes. Resveratrolpossesses antioxidative properties which have shown to reduce the oxidative damage from reactive oxygen species (ROS). Resveratrol also has the ability to attenuate inflammation via inhibiting TNF-a, IL-1b, IL-6, and blocking NF-kB activation. Resveratrol supplementation may have the potential to mitigate the damages associated with intense orprolonged exercise; consequently improving recovery. The purpose of this study is to evaluate the effects of a14 day prophylactic supplementation trans-resveratrol onTNF-a, IL-1b, and IL-6 from a single bout of eccentric exercise in traineddistance runners.